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KMID : 1134820180470020143
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Journal of the Korean Society of Food Science and Nutrition
2018 Volume.47 No. 2 p.143 ~ p.149
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Protective Effects of Lamb Placenta on UVB-Induced Keratinocytes and IBMX-Induced Melanocytes
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Lee Da-Som
Lee Min-Hee
Park Soo-Jeung
Yun Jeong-Moon
Kim Da-Kyung
Kim Ji-Hoon
Lee Min-Jae
Woo Young-Ho
Lee Jeong-Min
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Abstract
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In this study, we investigated the protective effects of lamb placenta on UVB-induced keratinocytes and 3-isobutyl-1-methylxanthine (IBMX)-induced melanocytes. HaCaT cells were stimulated by UVB 50 mJ/cm2, which induced increases in cell death and pro-inflammatory cytokine production and decreases in hyaluronic acid synthase (HAS) mRNA expression. However, placenta treatment inhibited UVB-induced cell death and pro-inflammatory cytokine production and increased HAS. In IBMX-induced melanocytes, placenta treatment suppressed melanin production. In addition, placenta treatment directly inhibited tyrosinase activation. In conclusion, these results show that lamb placenta has protective effects against UVB-induced keratinocyte damage and IBMX-induced melanocytes. Thus, we suggest that lamb placenta is effective as a cosmeceutical ingredient.
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KEYWORD
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lamb placenta, keratinocytes, melanocytes, skin health, melanin
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